cd4 cd25 regulatory t lymphocytes in allergy and asthma ,成果详细信息-全讯担保网

您当前所在位置: 全讯担保网-0008全讯注册 > 学者

施焕中

  • 74浏览

  • 0点赞

  • 0收藏

  • 1分享

  • 211下载

  • 0评论

  • 引用

期刊论文

cd4 cd25 regulatory t lymphocytes in allergy and asthma

, ,

allergy 2005: 60: 986-995,-0001,():

url:

摘要/描述

allergic asthma is characterized by airway hyper-responsiveness and chronic mucosal inflammation mediated by cd4 th2 lymphocytes. regulatory cd4 cd25 t cells are important components of the homeostasis of the immune system, as impaired cd4 cd25 t cell activity can cause autoimmune diseases and allergy. the mechanism of suppression by cd4 cd25 t cells remains controversial; different in vivo and in vitro studies raise possible roles for the immunosuppressive cytokines interleukin-10 and transforming growth factor-β, forkhead transcription factor foxp3, glucocorticoid-induced tumor necrosis factor receptor, cytotoxic lymphocyte associated antigen-4, 4-1bb costimulator receptor, a cd4-related molecule lag-3, and neuropilin-1. current data suggest that th2 responses to allergens are normally suppressed by cd4 cd25 t cells. suppression by cd4 cd25 t cells is decreased in allergic individuals. furthermore, cd4 cd25 t cells play a key role in regulating airway eosinophilic inflammation. the immunomodulatory properties of cd4 cd25 t cells do extend to th2 responses, most notably by limiting the development of a proinflammatory cd4 th2 phenotype characterized by reduced cytokine production. an understanding of the roles of cd4 cd25 t cells in vivo could provide better insight into the design of novel approaches to modulate the chronic airway inflammatory reaction evident in bronchial asthma.

关键词:
  • 问答

    暂无问题,成为第一个提问者

【免责声明】以下全部内容由[施焕中]上传于[2006年01月19日 22时50分06秒],全讯担保网的版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。

我要评论

全部评论 0

本学者其他成果

同领域成果

网站地图