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synthesis of cluster mannosides via a ugi four-component reaction and their inhibition against the binding of yeast mannan to concanavalin a

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carbohydrate research 339(2004)873-879,-0001,():

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摘要/描述

the ugifour-component reaction (u-4cr) was utilized to prepare divalent and trivalent cluster mannosides with different scaolds. the glycoclusters obtained were tested for their relative inhibitory potency against the binding of yeast mannan to concanavalin a by solid-phase enzyme-linked lectin assays (ella) using methyl a-d-mannopyranoside as a standard. among them, a divalent mannoside containing aromatic groups showed the strongest binding affinity to concanavalin a.

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