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通过α,β-不饱和酮构建四氢化萘
首发时间：2025-03-14
摘要：四氢化萘作为一种重要的有机合成砌块，常参与组成有机小分子的核心骨架。至今，科学家们已经发展出不同的构建路径，但拓展其高效多样的合成策略仍具有重要意义。本文开发出一种新颖的四氢化萘稠环构筑方式，该途径选用廉价易得的α,β-不饱和酮和1,2-二(溴甲基)苯作为起始原料，在铁粉和溴化钠的作用下，完成了分子间的[4 2]环化，以极佳的收率得到了一系列的四氢化萘衍生物。该方法不仅拓展了四氢化萘的合成方法，还为后续相关化合物的性质研究提供了物质基础。
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construction of tetrahydronaphthalene via α,β-unsaturated ketones
abstract：tetrahydronaphthalene, as an important building block in organic synthesis, frequently serves as the core framework of small organic molecules. to date, various synthetic approaches have been developed for its construction; however, expanding efficient and diverse synthetic strategies remains of great significance.in this study, we developed a novel fused tetrahydronaphthalene construction strategy. this approach employs inexpensive and readily available α,β-unsaturated ketones and 1,2-bis(bromomethyl)benzene as starting materials. under the action of iron powder and sodium bromide, an intermolecular [4 2] cyclization was successfully achieved, affording a series of tetrahydronaphthalene derivatives in excellent yields. this method not only expands the synthetic toolbox for tetrahydronaphthalenes but also provides a valuable foundation for further investigation into the properties of related compounds.
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