提示
乳腺肿瘤基线血管灌注功能对免疫检查点治疗的影响
首发时间：2024-07-09
摘要：免疫检查点阻断（immune checkpoint blockade，icb）疗法仅让小部分病人长期获益，其耐受机制还不完全清楚。前期研究表明icb可以提高肿瘤血管的灌注功能和诱导血管正常化，且血管正常化程度与其疗效呈正相关。那么，治疗前肿瘤血管的灌注功能状态是否影响icb治疗的敏感性？在原位eo771乳腺肿瘤模型，pd1抗体治疗显著抑制基线高灌注肿瘤的生长、增加瘤内cd8 t细胞的比例和提高肿瘤血管灌注功能，而对基线低灌注肿瘤则没有这些影响。与基线低灌注肿瘤相比，基线高灌注肿瘤中有较多的效应型cd8 t细胞且大多数与功能血管共定位，而免疫抑制性细胞则较少。这些实验结果表明治疗前肿瘤血管的灌注功能状态显著影响icb治疗的敏感性，这可能与其浸润的cd8 t细胞特征有关。
关键词：
for information in english, please click here
the impacts of baseline tumor vessel perfusion on immune checkpoint therapy
abstract：immune checkpoint blockade (icb) therapy only benefits a small fraction of cancer patients, and the underlying mechanism is not fully understood. previous studies have shown that icb can improve tumor vessel perfusion and induce vascular normalization, and the degree of vascular normalization is positively correlated with its efficacy. then, does the perfusion status of tumor blood vessels before treatment affect the sensitivity of icb therapy? in the orthotopic eo771 breast tumor model, anti-pd1 treatment significantly inhibited the growth of tumors with high baseline perfusion, increased the proportions of intratumoral cd8 t cells, and improved tumor vascular perfusion, while there were no such effects on tumors with low baseline perfusion. compared to tumors with low baseline perfusion, tumors with high baseline perfusion contained more effector cd8 t cells and less immunosuppressive cells. moreover, most of cd8 t cells were co-localized with functional blood vessels. the datasuggest that baseline tumor vessel perfusion significantly affects the sensitivity of icb therapy, which may be related to the characteristics of iintratumoral cd8 t cells.
keywords：
基金：
论文图表：
引用
导出参考文献
no.****
动态公开评议
共计0人参与
勘误表
乳腺肿瘤基线血管灌注功能对免疫检查点治疗的影响
评论
全部评论