提示
四个短肽代谢物对t细胞增殖、迁移和功能的体外效应
首发时间：2024-04-22
摘要：目的：前期我们将t细胞淋巴瘤患者血浆的代谢组与t细胞mrna表达谱进行了相关性分析，筛选出一些与t细胞调控基因有显著相关的肽类代谢物：alanyl-isoleucine（ai）、isoleucyl-isoleucine（ii）、isoleucyl-tryptophan（it）、methionine-serine-arginine（msa）。方法：流式细胞术检测t细胞分泌和功能相关marker、羧基荧光素琥珀酰亚胺酯（cfse）染料检测t细胞增殖实验、transwell法检测t细胞体外迁移实验。结论：只有msa对t细胞增殖有剂量依赖性的抑制效应、对t细胞迁移有明显促进作用。?????
关键词： t细胞 增殖 迁移 短肽代谢物?????
for information in english, please click here
effects of four short peptide metabolites on t cell proliferation,migration,and fuction in votro
abstract：purpse: we analyzed the correlation between the plasma metabome and t cell mrna expression profile of t cell lymphoma patients, and screened some peptide metabolites that were significantly related to t cell regulatory genes: alanyl-isoleucine (ai), isoleucyl-isoleucine (ii), isoleucyl-tryptophan (it), methionine serine-arginine (msa).methods: t cell secretion and function related markers were detected by flow cytometry, t cell proliferation was detected by carboxyfluorescein succinimidyl ester (cfse) dye, and t cell migration was detected by transwell in vitro. results:only msa could inhibit t cell proliferation and promote t cell migration in a dose-dependent manner.
keywords： t cells proliferation migration short peptides
基金：
论文图表：
引用
导出参考文献
no.****
动态公开评议
共计0人参与
勘误表
四个短肽代谢物对t细胞增殖、迁移和功能的体外效应
评论
全部评论