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氟化铈钠纳米闪烁晶体用于肿瘤声动力治疗
首发时间：2024-03-15
摘要：[目的]发展一种新型高效、安全的声敏剂用于肿瘤声动力治疗（sonodynamic therapy，sdt），克服传统肿瘤治疗存在的局限性。[方法] 通过高温热分解法，调整原料比例，合成一系列闪烁晶体，并进行筛选，以此进行后续声敏化效率的验证，以及探索这种基于scnds的sdt在体外和体内水平的效果。[结果] 高温热分解法能够合成出形貌均一的闪烁纳米点（scintillating nanodots, scnds）。基于声敏化效率筛选出的scnd-peg能够通过消耗谷胱甘肽（glutathione，gsh）在超声（ultrasound，us）作用下进一步提高活性氧（reactive oxygen species，ros）的产率，在细胞及动物水平展示出优异的sdt效果。[结论] 本研究结果表明scnd-peg具有良好的sdt效果，可以在肿瘤治疗，甚至未来在其他疾病中发挥新的作用。
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nacefx:gd,tb nanoscintillator used for cancer sonodynamic therapy
abstract：[objective] to develop a novel highly effective and safe sonosensitizer for tumor sonodynamic therapy (sonodynamic therapy, sdt) to overcome the limitations of traditional tumor treatment. [methods] a series of scintillators were synthesized and selected by high-temperature thermal decomposition to verify the efficiency of subsequent acoustic sensitization and to explore the effects of this scnts-based sdt at both in vitro and in vivo levels.[results]scintillating nanodots (scnds) with uniform morphology were synthesized. scnd-peg selected based on acoustic sensitization efficiency can further improve the production rate of reactive oxygen species (ros) under the action of ultrasound, us by consuming glutathione (gsh). excellent sdt effects were demonstrated at the cellular and animal levels. [conclusion]the results of this study show that the scnd-peg has a good sdt effect, and can play a new role in tumor treatment and even in other diseases in the future.
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氟化铈钠纳米闪烁晶体用于肿瘤声动力治疗
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